The first large population based twin study of coeliac disease

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The first large population based twin study of coeliac disease.

BACKGROUND AND AIMS The genetic load in coeliac disease has hitherto been inferred from case series or anecdotally referred twin pairs. We have evaluated the genetic component in coeliac disease by estimating the concordance rate for the disease among twin pairs in a large population based study. METHODS The Italian Twin Registry was matched with the membership lists of a patient support grou...

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SMALL INTESTINE The first large population based twin study of coeliac disease

L Greco, R Romino, I Coto, N Di Cosmo, S Percopo, M Maglio, F Paparo, V Gasperi, M G Limongelli, R Cotichini, C D’Agate, N Tinto, L Sacchetti, R Tosi, M A Stazi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

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Coeliac disease in identical twin infants.

Case reports Male twins, aged 19 years Both boys vomited during weaning at the age of 7 months. They were admitted 10 months later because of weight loss and recurring vomiting, and their faecal-fat excretion was 44% and 48%. Both children recovered when given a gluten-free diet. At the age of 11 years, their bone age was 10 years. They then returned to a normal diet, although continuing to hav...

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Identification of twin pairs from large population-based samples.

The basis of most twin studies is the ascertainment of twins, often through twin registries, and determination of zygosity. The current rate of twin births in many industrialized countries implies that in the near future around 3% or more of individuals will be a twin. Hence, there are and will be a lot of twins around and many of those will not participate in twin studies. However, if large po...

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ژورنال

عنوان ژورنال: Gut

سال: 2002

ISSN: 0017-5749

DOI: 10.1136/gut.50.5.624